HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Wang, Haichao; Bloom, Ona; Zhang, Minghuang; M. Vishnubhakat, Jaideep; Ombrellino, Michael; Che, Jiantu; Frazier, Asia; Yang, Huan; Ivanova, Svetlana; V. Borovikova, L.; R. Manogue, Kirk; Faist, Eugen; Abraham, Edward; Andersson, Jan; Andersson, Ulf; E. Molina, Patricia; N. Abumrad, Naji; E. Sama, Andrew; J. Tracey, Kevin

doi:10.1126/science.285.5425.248

Public

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Published in Science • Jul 9, 1999

Authors:

Haichao Wang

Ona Bloom

Minghuang Zhang

Abstract

Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical tria...

Subject

Mediator

Lethality

Tumor necrosis factor alpha

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