Pathway to Synthesis and Processing of Mycolic Acids in
            <i>Mycobacterium tuberculosis</i>

Takayama, Kuni; Wang, Cindy; S. Besra, Gurdyal

doi:10.1128/cmr.18.1.81-101.2005

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Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis

Shared by NobleBlocks on Jan 1, 2005 • 12:00 AM UTC

Authors:

Kuni Takayama

Cindy Wang

Gurdyal S. Besra

Abstract

SUMMARY Mycobacterium tuberculosis is known to synthesize α-, methoxy-, and keto-mycolic acids. We propose a detailed pathway to the biosynthesis of all mycolic acids in M. tuberculosis . Fatty acid synthetase I provides C 20 -S-coenzyme A to the fatty acid synthetase II system (FAS-IIA). Modules of...

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