Identification of genes conferring resistance to 5-fluorouracil

Kwon Yoo, Byoung; Gredler, Rachel; Vozhilla, Nicollaq; Su, Zao-zhong; Dong, Chen; Forcier, Talitha; Shah, Khalid; Saxena, Utsav; Hansen, Ulla; B. Fisher, Paul; Sarkar, Devanand

doi:10.1073/pnas.0901451106

Public

Identification of genes conferring resistance to 5-fluorouracil

Published in Proceedings of the National Academy of Sciences • Jul 21, 2009

Authors:

Byoung Kwon Yoo

Rachel Gredler

Nicollaq Vozhilla

Abstract

Astrocyte elevated gene-1 (AEG-1) is overexpressed in >90% of human hepatocellular carcinoma (HCC) patients and plays a significant role in mediating aggressive progression of HCC. AEG-1 is known to augment invasion, metastasis, and angiogenesis, and we now demonstrate that AEG-1 directly contribute...

Subject

Dihydropyrimidine dehydrogenase

DPYD

Thymidylate synthase

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