Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Wessel, Jennifer; Y. Chu, Audrey; M. Willems, Sara; Wang, Shuai; Yaghootkar, Hanieh; A. Brody, Jennifer; Dauriz, Marco; Hivert, Marie‐France; Raghavan, Sridharan; Lipovich, Leonard; Hidalgo, Bertha; Fox, Keolu; E. Huffman, Jennifer; An, Ping; Lu, Yingchang; J. Rasmussen‐Torvik, Laura; Grarup, Niels; G. Ehm, Margaret; Li, Li; S. Baldridge, Abigail; Stančáková, Alena; Abrol, Ravinder; Besse, Céline; Boland, Anne; Bork‐Jensen, Jette; Fornage, Myriam; F. Freitag, Daniel; E. Garcia, Melissa; Guo, Xiuqing; Hara, Kazuo; Isaacs, Aaron; Jakobsdóttir, Jóhanna; A. Lange, Leslie; Layton, Jill; Li, Man; Zhao, Wei; Meidtner, Karina; C. Morrison, Alanna; A. Nalls, Mike; J. Peters, Marjolein; Sabater‐Lleal, Maria; Schurmann, Claudia; Silveira, Angela; V. Smith, Albert; Southam, Lorraine; H. Stoiber, Marcus; J. Strawbridge, Rona; D. Taylor, Kent; V. Varga, Tibor; H. Allin, Kristine; Amin, Najaf; L. Aponte, Jennifer; Aung, Tin; Barbieri, Caterina; A. Bihlmeyer, Nathan; Boehnke, Michael; Bombieri, Cristina; W. Bowden, Donald; M. Burns, Sean; Chen, Yuning; Chen, Yii-DerI; Cheng, Ching‐Yu; Correa, Adolfo; Czajkowski, Jacek; Dehghan, Abbas; Ehret, Georg; Eiríksdóttir, Guðný; Andersson Escher, Stefan; Farmaki, Aliki‐Eleni; Frånberg, Mattias; Gambaro, Giovanni; Giulianini, Franco; A. Goddard, William; Goel, Anuj; Gottesman, Omri; L. Grove, Megan; Gustafsson, Stefan; Hai, Yang; Hallmans, Göran; Heo, Jiyoung; Hoffmann, Per; Kamran Ikram, M.; A. Jensen, Richard; E. Jørgensen, Marit; Jørgensen, Torben; Karaleftheri, Maria; Chuen Khor, Chiea; Kirkpatrick, Andrea; T. Kraja, Aldi; Kuusisto, Johanna; M. Lange, Ethan; T. Lee, I.; Lee, Wen‐Jane; Leong, Aaron; Liao, Jiemin; Liu, Chunyu; Liu, Ching‐Ti; M. Lindgren, Cecilia; Linneberg, Allan; Malerba, Giovanni; Mamakou, Vasiliki; Marouli, Eirini; M. Maruthur, Nisa; Matchan, Angela; McKean‐Cowdin, Roberta; McLeod, Olga; Metcalf, Ginger; L. Mohlke, Karen; M. Muzny, Donna; Ντάλλα, Ιωάννα; D Palmer, Nicholette; Pasko, Dorota; Peter, Andreas; W. Rayner, Nigel; Renström, Frida; Rice, Kenneth; Sala, Cinzia; Sennblad, Bengt; Serafetinidis, Ioannis; A. Smith, Jennifer; Soranzo, Nicole; K. Speliotes, Elizabeth; A. Stahl, Eli; Stirrups, Kathleen; Tentolouris, N.; Thanopoulou, Anastasia; Torres, Mina; Traglia, Michela; Tsafantakis, Emmanouil; Javad, Sundas; R. Yanek, Lisa; Zengini, Eleni; M. Becker, Diane; C Bis, Joshua; Brown, James; Adrienne Cupples, L.; Hansen, Torben; Ingelsson, Erik; J. Karter, Andrew; Lorenzo, Carlos; A. Mathias, Rasika; M. Norris, Jill; M. Peloso, Gina; H.-H. Sheu, Wayne; Toniolo, Daniela; Vaidya, Dhananjay; Varma, Rohit; E. Wagenknecht, Lynne; Boeing, Heiner; P. Böttinger, Erwin; Dedoussis, George; Deloukas, Panos; Ferrannini, Ele; H. Franco, Oscar; W. Franks, Paul; A. Gibbs, Richard; Guðnason, Vilmundur; Hamsten, Anders; B. Harris, Tamara; T. Hattersley, Andrew; Hayward, Caroline; Hofman, Albert; Jansson, Jan-Håkan; Langenberg, Claudia; J. Launer, Lenore; Levy, Daniel; A. Oostra, Ben; J. O’Donnell, Christopher; O’Rahilly, Stephen; Padmanabhan, Sandosh; S. Pankow, James; Polašek, Ozren; A. Province, Michael; S. Rich, Stephen; M. Ridker, Paul; Rudan, Igor; B. Schulze, Matthias; H. Smith, Blair; G. Uitterlinden, André; Walker, Mark; Watkins, Hugh; Yin Wong, Tien; Zeggini, Eleftheria; J. Sharp, Stephen; G. Forouhi, Nita; D. Kerrison, Nicola; Lucarelli, Debora; Sims, Matt; Barroso, Inês; I. McCarthy, Mark; Arriola, Larraitz; Balkau, Beverley; Barricarte, Aurelio; A. González, Carlos; Grioni, Sara; Kaaks, Rudolf; J. Key, Timothy; Navarro, Carmen; M. Nilsson, Peter; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Ramón Quirós, J.; Rolandsson, Olov; Sacerdote, Carlotta; Sánchez, María‐José; Slimani, Nadia; Tjønneland, Anne; ­Tumino, ­Rosario; L. van der A, Daphne; T. van der Schouw, Yvonne; Ríboli, Elio; Laakso, Markku; B. Borecki, Ingrid; I. Chasman, Daniel; Pedersen, Oluf; M. Psaty, Bruce; Shyong Tai, E; M. van Duijn, Cornelia; J. Wareham, Nicholas; Waterworth, Dawn; Boerwinkle, Eric; Linda Kao, W.H.; C. Florez, José; J. F. Loos, Ruth; G. Wilson, James; M. Frayling, Timothy; S. Siscovick, David; Dupuis, Josée; I. Rotter, Jerome; B. Meigs, James; A. Scott, Robert; O. Goodarzi, Mark

doi:10.1038/ncomms6897

Public

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Published in Nature Communications • Jan 29, 2015

Authors:

Jennifer Wessel

Audrey Y. Chu

Sara M. Willems

Abstract

Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of ...

Subject

Exome

Type 2 diabetes

Exome sequencing

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