Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells.

AJ, Galliher; WP, Schiemann

doi:10.1186/bcr1524

Public

Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells.

Shared by NobleBlocks on Jan 1, 2006 • 12:00 AM UTC

Authors:

Galliher AJ

Schiemann WP

Abstract

Introduction Transforming growth factor (TGF)-beta suppresses breast cancer formation by preventing cell cycle progression in mammary epithelial cells (MECs). During the course of mammary tumorigenesis, genetic and epigenetic changes negate the cytostatic actions of TGF-beta, thus enabling TGF-beta ...

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