β3Integrin and Src facilitate transforming growth factor-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cells

J Galliher, Amy; P. Schiemann, William

doi:10.1186/bcr1524

Public

β3Integrin and Src facilitate transforming growth factor-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cells

Published in Breast Cancer Research • Jul 19, 2006

Authors:

Amy J Galliher

William P. Schiemann

Abstract

INTRODUCTION: Transforming growth factor (TGF)-beta suppresses breast cancer formation by preventing cell cycle progression in mammary epithelial cells (MECs). During the course of mammary tumorigenesis, genetic and epigenetic changes negate the cytostatic actions of TGF-beta, thus enabling TGF-beta...

Subject

Surgical oncology

Epithelial–mesenchymal transition

Transforming growth factor

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