Distinct DNA methylomes of newborns and centenarians

Heyn, Holger; Li, Ning; J. Ferreira, Humberto; Morán, Sebastián; G. Pisano, David; Gómez, Antonio; Diez, Javier; V. Sánchez‐Mut, José; Setién, Fernando; Javier Carmona, F.; Alessandro Puca, Annibale; Sayols, Sergi; Ángel Pujana, Miguel; Serra-Musach, Jordi; Iglesias‐Platas, Isabel; Formiga, Francesç; F. Fernández, Agustín; F. Fraga, Mario; Heath, Simon; Valencia, Alfonso; Gut, Marta; Wang, Jun; Esteller, Manel

doi:10.1073/pnas.1120658109

Public

Distinct DNA methylomes of newborns and centenarians

Published in Proceedings of the National Academy of Sciences • Jun 11, 2012

Authors:

Holger Heyn

Ning Li

Humberto J. Ferreira

Abstract

Human aging cannot be fully understood in terms of the constrained genetic setting. Epigenetic drift is an alternative means of explaining age-associated alterations. To address this issue, we performed whole-genome bisulfite sequencing (WGBS) of newborn and centenarian genomes. The centenarian DNA ...

Subject

Centenarian

DNA methylation

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