Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

Antônio Campos, Marco; C. Almeida, Igor; Takeuchi, Osamu; Akira, Shizuo; P. Valente, Eneida; O. Procópio, Daniela; R. Travassos, Luiz; A. Smith, Jason; T. Golenbock, Douglas; T. Gazzinelli, Ricardo

doi:10.4049/jimmunol.167.1.416

Public

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

Published in The Journal of Immunology • Jul 1, 2001

Authors:

Marco Antônio Campos

Igor C. Almeida

Osamu Takeuchi

Abstract

Glycosylphosphatidylinositol (GPI) anchors and glycoinositolphospholipids (GIPLs) from parasitic protozoa have been shown to exert a wide variety of effects on cells of the host innate immune system. However, the receptor(s) that are triggered by these protozoan glycolipids has not been identified. ...

Subject

Trypanosoma cruzi

Chinese hamster ovary cell

Biology

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