Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

S. Anderson, Mark; S. Venanzi, Emily; Klein, Ludger; Chen, Zhibin; P. Berzins, Stuart; J. Turley, Shannon; von Boehmer, Harald; Bronson, Roderick; Dierich, Andrée; Benoist, Christophe; Mathis, Diane

doi:10.1126/science.1075958

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Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Shared by NobleBlocks on Nov 15, 2002 • 12:00 AM UTC

Authors:

Mark S. Anderson

Emily S. Venanzi

Ludger Klein

Abstract

Humans expressing a defective form of the transcription factor AIRE (autoimmune regulator) develop multiorgan autoimmune disease. We used aire - deficient mice to test the hypothesis that this transcription factor regulates autoimmunity by promoting the ectopic expression of peripheral tissue– restr...

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