The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

C. Morton, A.; Rothman, Alexander; P. Greenwood, John; Gunn, Julian; Chase, Alexander; Clarke, Bernard; S. Hall, Alistair; A.A. Fox, Keith; Foley, Claire; Banya, Winston; Wang, Duolao; Flather, Marcus; C. Crossman, David

doi:10.1093/eurheartj/ehu272

Public

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

Published in European Heart Journal • Jul 30, 2014

Authors:

A. C. Morton

Alexander Rothman

John P. Greenwood

Abstract

AIMS: Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation. We hypothesized that if IL-1 is a driving influence of inf...

Subject

Medicine

Placebo

C-reactive protein

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