Culture independent analysis of ileal mucosa reveals a selective increase in invasive <i>Escherichia coli</i> of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum

Baumgart, Martin; Dogan, Belgin; Rishniw, Mark; Weitzman, Gil; P. Bosworth, Brian; K. Yantiss, Rhonda; H. Orsi, Renato; Wiedmann, Martin; L. McDonough, Patrick; Guk Kim, Sung; E. Berg, Douglas; Schukken, Y.H.; Scherl, Ellen; W. Simpson, Kenneth

doi:10.1038/ismej.2007.52

Public

Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum

Published in The ISME Journal • Jul 12, 2007

Authors:

Martin Baumgart

Belgin Dogan

Mark Rishniw

Abstract

Intestinal bacteria are implicated increasingly as a pivotal factor in the development of Crohn's disease, but the specific components of the complex polymicrobial enteric environment driving the inflammatory response are unresolved. This study addresses the role of the ileal mucosa-associated micro...

Subject

Biology

Microbiology

Ileum

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