Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells

U. Ahmed, Shafiq; Carruthers, Ross; Gilmour, Lesley; Yildirim, Salih; Watts, Colin; J. Chalmers, Anthony

doi:10.1158/0008-5472.can-14-3790

Public

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells

Published in Cancer Research • Aug 17, 2015

Authors:

Shafiq U. Ahmed

Ross Carruthers

Lesley Gilmour

Abstract

Glioblastoma is the most common form of primary brain tumor in adults and is essentially incurable. Despite aggressive treatment regimens centered on radiotherapy, tumor recurrence is inevitable and is thought to be driven by glioblastoma stem-like cells (GSC) that are highly radioresistant. DNA dam...

Subject

Radioresistance

Radiosensitivity

DNA damage

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