Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Vétizou, Marie; M. Pitt, Jonathan; Daillère, Romain; Lepage, Patricia; Waldschmitt, Nadine; Flament, Caroline; Rusakiewicz, Sylvie; Routy, Bertrand; P. Roberti, María; P.M. Duong, Connie; Poirier-Colame, Vichnou; Roux, Antoine; Becharef, Sonia; C. Formenti, Silvia; B. Golden, Encouse; Cording, Sascha; Eberl, Gérard; Schlitzer, Andreas; Ginhoux, Florent; Mani, Sridhar; Yamazaki, Takahiro; Jacquelot, Nicolas; Enot, David; Bérard, M; Nigou, Jérôme; Opolon, Paule; Eggermont, Alexander; Woerther, Paul‐Louis; Chachaty, Élisabeth; Chaput, Nathalie; Robert, Caroline; Mateus, Christina; Kroemer, Guido; Raoult, Didier; G. Boneca, Ivo; Carbonnel, Franck; Chamaillard, Mathias; Zitvogel, Laurence

doi:10.1126/science.aad1329

Public

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Published in Science • Nov 5, 2015

Authors:

Marie Vétizou

Jonathan M. Pitt

Romain Daillère

Abstract

Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In mice and patients, T cell responses specific for B. thetaiotaomicron or B. fragilis were associated with the efficacy of C...

Subject

CTLA-4

Blockade

Immunotherapy

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