Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

Ponomaryov, Tanya; Peled, Amnon; Petit, Isabelle; S. Taichman, Russell; Habler, Liliana; Sandbank, Judith; Arenzana‐Seisdedos, Fernando; Magérus, Aude; Carúz, Antonio; Fujii, Nobutaka; Nagler, Arnon; Lahav, Meir; Szyper-Kravitz, Martin; Zipori, Dov; Lapidot, Tsvee

doi:10.1172/jci10329

Public

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

Published in Journal of Clinical Investigation • Dec 1, 2000

Authors:

Tanya Ponomaryov

Amnon Peled

Isabelle Petit

Abstract

The chemokine stromal-derived factor-1 (SDF-1) controls many aspects of stem cell function. Details of its regulation and sites of production are currently unknown. We report that in the bone marrow, SDF-1 is produced mainly by immature osteoblasts and endothelial cells. Conditioning with DNA-damagi...

Subject

Homing (biology)

Stem cell

Stromal cell

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