Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

Amar, Jacques; Chabo, Chantal; Waget, Aurélie; Klopp, Pascale; Vachoux, Christelle; G. Bermúdez‐Humarán, Luis; Smirnova, Natalia; Bergé, Mathieu; Sulpice, Thierry; J. Lahtinen, Sampo; C. Ouwehand, Arthur; Langella, Philippe; Rautonen, Nina; Sansonetti, Philippe; Burcelin, Rémy

doi:10.1002/emmm.201100159

Public

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

Published in EMBO Molecular Medicine • Jul 4, 2011

Authors:

Jacques Amar

Chantal Chabo

Aurélie Waget

Abstract

A fat-enriched diet modifies intestinal microbiota and initiates a low-grade inflammation, insulin resistance and type-2 diabetes. Here, we demonstrate that before the onset of diabetes, after only one week of a high-fat diet (HFD), live commensal intestinal bacteria are present in large numbers in ...

Subject

Probiotic

Chromosomal translocation

Bacterial translocation

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