Therapeutic Efficacy of a Novel Focal Adhesion Kinase Inhibitor TAE226 in Ovarian Carcinoma

Halder, Jyotsnabaran; G. Lin, Yvonne; M. Merritt, William; A. Spannuth, Whitney; M. Nick, Alpa; Honda, Toshiyuki; A. Kamat, Aparna; Y. Han, Liz; Jin Kim, Tae; Lu, Chunhua; M. Tari, Ana; Bornmann, William; Fernandez, Ariel; Lopez-Berestein, Gabriel; K. Sood, Anil

doi:10.1158/0008-5472.can-07-2667

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Therapeutic Efficacy of a Novel Focal Adhesion Kinase Inhibitor TAE226 in Ovarian Carcinoma

Shared by NobleBlocks on Nov 15, 2007 • 12:00 AM UTC

Authors:

Jyotsnabaran Halder

Yvonne G. Lin

William M. Merritt

Abstract

Abstract Focal adhesion kinase (FAK) overexpression is frequently found in ovarian and other cancers and is predictive of poor clinical outcome. In the current study, we characterized the biological and therapeutic effects of a novel FAK inhibitor, TAE226. Taxane-sensitive (SKOV3ip1 and HeyA8) and t...

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