Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells

Ferlazzo, Guido; L. Tsang, Ming; Moretta, Lorenzo; Melioli, Giovanni; M. Steinman, Ralph; Münz, Christian

doi:10.1084/jem.20011149

Public

Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells

Published in The Journal of Experimental Medicine • Feb 4, 2002

Authors:

Guido Ferlazzo

Ming L. Tsang

Lorenzo Moretta

Abstract

During the innate response to many inflammatory and infectious stimuli, dendritic cells (DCs) undergo a differentiation process termed maturation. Mature DCs activate antigen-specific naive T cells. Here we show that both immature and mature DCs activate resting human natural killer (NK) cells. With...

Subject

Interleukin 12

Biology

Cell biology

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