The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-24

G. Caudell, Eva; B. Mumm, John; Poı̀ndexter, Nancy; Ekmekçioglu, Sühendan; M. Mhashilkar, Abner; Yang, Xiaohong; W. Retter, Mark; A. Hill, Paul; Chada, Sunil; A. Grimm, Elizabeth

doi:10.4049/jimmunol.168.12.6041

Public

The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-24

Published in The Journal of Immunology • Jun 1, 2002

Authors:

Eva G. Caudell

John B. Mumm

Nancy Poı̀ndexter

Abstract

The melanoma differentiation-associated gene 7 (mda-7) has been studied primarily in the context of its tumor suppressor activity. Although mda-7 has been designated as IL-24 based on its gene location in the IL-10 locus and its mRNA expression in leukocytes, no functional evidence supporting this c...

Subject

Peripheral blood mononuclear cell

Biology

Cytokine

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