Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation

K. Forwood, Jade; Thakur, Anil; Gunčar, Gregor; Marfori, Mary; Mouradov, Dmitri; Meng, Weining; A. Robinson, J.; Huber, Thomas; Kellie, Stuart; L. Martin, Jennifer; Hume, David; Kobe, Boštjan

doi:10.1073/pnas.0700974104

Public

Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation

Published in Proceedings of the National Academy of Sciences • Jun 12, 2007

Authors:

Jade K. Forwood

Anil Thakur

Gregor Gunčar

Abstract

Acyl-CoA thioesterases (Acots) catalyze the hydrolysis of fatty acyl-CoA to free fatty acid and CoA and thereby regulate lipid metabolism and cellular signaling. We present a comprehensive structural and functional characterization of mouse acyl-CoA thioesterase 7 (Acot7). Whereas prokaryotic homolo...

Subject

Thioesterase

Biochemistry

Enzyme

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