Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

BACKGROUND: The proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18 are central players in the pathogenesis of inflammatory bowel disease (IBD). In response to a variety of microbial components and crystalline substances, both cytokines are processed via the caspase-1-activating multipr... View More