Type II Toxoplasma gondiiKU80Knockout Strains Enable Functional Analysis of Genes Required for Cyst Development and Latent Infection

A. Fox, Barbara; Falla, Alejandra; M. Rommereim, Leah; Tomita, Tadakimi; P. Gigley, Jason; Mercier, Corinne; Cesbron‐Delauw, Marie‐France; M. Weiss, Louis; J. Bzik, David

doi:10.1128/ec.00297-10

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Type II Toxoplasma gondiiKU80Knockout Strains Enable Functional Analysis of Genes Required for Cyst Development and Latent Infection

Published in Eukaryotic Cell • Apr 30, 2011

Authors:

Barbara A. Fox

Alejandra Falla

Leah M. Rommereim

Abstract

Type II Toxoplasma gondii KU80 knockouts (Δku80) deficient in nonhomologous end joining were developed to delete the dominant pathway mediating random integration of targeting episomes. Gene targeting frequency in the type II Δku80 Δhxgprt strain measured at the orotate (OPRT) and the uracil (UPRT) ...

Subject

Biology

Toxoplasma gondii

Gene

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