MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

Chen, Lin; Chen, Kaifu; A. Lavery, Laura; Andrew Baker, Steven; A. Shaw, Chad; Li, Wei; Y. Zoghbi, Huda

doi:10.1073/pnas.1505909112

Public

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

Published in Proceedings of the National Academy of Sciences • Apr 13, 2015

Authors:

Lin Chen

Kaifu Chen

Laura A. Lavery

Abstract

Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to afford the genome flexibility in responding to developmental and environmental cues in health and disease. A prime example involving epigenetic dysfunction is the postnatal neurodevelopmental disorder Rett syndrome ...

Subject

MECP2

Rett syndrome

DNA methylation

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