Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

L, Jones; PA, Holmans; ML, Hamshere; D, Harold; V, Moskvina; D, Ivanov; A, Pocklington; R, Abraham; P, Hollingworth; R, Sims; A, Gerrish; JS, Pahwa; N, Jones; A, Stretton; AR, Morgan; S, Lovestone; J, Powell; P, Proitsi; MK, Lupton; C, Brayne; DC, Rubinsztein; M, Gill; B, Lawlor; A, Lynch; K, Morgan; KS, Brown; PA, Passmore; D, Craig; B, McGuinness; S, Todd; C, Holmes; D, Mann; AD, Smith; S, Love; PG, Kehoe; S, Mead; N, Fox; M, Rossor; J, Collinge; W, Maier; F, Jessen; B, Schürmann; R, Heun; H, Kölsch; den Bussche H, van; I, Heuser; O, Peters; J, Kornhuber; J, Wiltfang; M, Dichgans; L, Frölich; H, Hampel; M, Hüll; D, Rujescu; AM, Goate; JS, Kauwe; C, Cruchaga; P, Nowotny; JC, Morris; K, Mayo; G, Livingston; NJ, Bass; H, Gurling; A, McQuillin; R, Gwilliam; P, Deloukas; A, Al-Chalabi; CE, Shaw; AB, Singleton; R, Guerreiro; TW, Mühleisen; MM, Nöthen; S, Moebus; KH, Jöckel; N, Klopp; HE, Wichmann; E, Rüther; MM, Carrasquillo; VS, Pankratz; SG, Younkin; J, Hardy; MC, O'Donovan; MJ, Owen; J, Williams

doi:10.1371/journal.pone.0013950

Public

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

Shared by NobleBlocks on Nov 15, 2010 • 12:00 AM UTC

Authors:

Jones L

Holmans PA

Hamshere ML

Abstract

Background Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!