Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

Jones, Lesley; Holmans, Peter; L. Hamshere, Marian; Harold, Denise; Moskvina, Valentina; Ivanov, Dobril; Pocklington, Andrew; Abraham, Richard; Hollingworth, Paul; Sims, Rebecca; Gerrish, Amy; Singh Pahwa, Jaspreet; Jones, Nicola; Stretton, Alexandra; R. Morgan, Angharad; Lovestone, Simon; Powell, John; Proitsi, Petroula; K. Lupton, Michelle; Brayne, Carol; C. Rubinsztein, David; Gill, Michael; Lawlor, Brian; Lynch, Aoibhinn; Morgan, Kevin; Brown, Kristelle; Passmore, Peter; Craig, David; McGuinness, Bernadette; Todd, Stephen; Holmes, Clive; Mann, David; David Smith, A.; Love, Seth; G. Kehoe, Patrick; Mead, Simon; C. Fox, Nick; N. Rossor, Martin; Collinge, John; Maier, Wolfgang; Jessen, Frank; Schürmann, Britta; van den Bussche, Hendrik; Heuser, Isabella; Peters, Oliver; Kornhuber, Johannes; Wiltfang, Jens; Dichgans, Martin; Frölich, Lutz; Hampel, Harald; Hüll, Michael; Rujescu, Dan; Goate, Alison; Kauwe, John; Cruchaga, Carlos; Nowotny, Petra; C. Morris, John; H. Mayo, Kevin; Livingston, Gill; Bass, Nicholas; Gurling, Hugh; McQuillin, Andrew; Gwilliam, Rhian; Deloukas, Panos; Al‐Chalabi, Ammar; E. Shaw, Christopher; B. Singleton, Andrew; Guerreiro, Rita; W. Mühleisen, Thomas; M. Nöthen, Markus; Moebus, Susanne; Jöckel, Karl‐Heinz; Klopp, Norman; Wichmann, H.‐Erich; Rüther, E.; M. Carrasquillo, Minerva; Shane Pankratz, V.; G. Younkin, Steven; Hardy, John; O‘Donovan, Michael; J. Owen, Michael; Williams, Julie

doi:10.1371/journal.pone.0013950

Public

Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

Published in PLoS ONE • Nov 15, 2010

Authors:

Lesley Jones

Peter Holmans

Marian L. Hamshere

Abstract

BACKGROUND: Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWA...

Subject

Genome-wide association study

Disease

Genetic association

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