Very Early Administration of Progesterone for Acute Traumatic Brain Injury

N. Goldstein, Joshua; D. Yeatts, Sharon; Silbergleit, Robert; Y. Palesch, Yuko; Hertzberg, Vicki; Frankel, Michael; C. Goldstein, Felicia; F. Caveney, Angela; Howlett-Smith, Harriet; M. Bengelink, Erin; T. Manley, Geoffrey; H. Merck, Lisa; Scott Janis, L.; G. Barsan, William

doi:10.1056/nejmoa1404304

Public

Very Early Administration of Progesterone for Acute Traumatic Brain Injury

Published in New England Journal of Medicine • Dec 10, 2014

Authors:

Joshua N. Goldstein

Sharon D. Yeatts

Robert Silbergleit

Abstract

BACKGROUND: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase trials involving patients with TBI. METHODS: We conducted a double-blind, multicenter clinical tr...

Subject

Traumatic brain injury

Medicine

Psychiatry

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