LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

Davis, Samuel; H. Aldrich, Thomas; Stahl, Neil; Li, Pan; Taga, Tetsuya; Kishimoto, Tadamitsu; Y. Ip, Nancy; D. Yancopoulos, George

doi:10.1126/science.8390097

Public

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

Published in Science • Jun 18, 1993

Authors:

Samuel Davis

Thomas H. Aldrich

Neil Stahl

Abstract

The ciliary neurotrophic factor (CNTF) receptor complex is shown here to include the CNTF binding protein (CNTFR alpha) as well as the components of the leukemia inhibitory factor (LIF) receptor, LIFR beta (the LIF binding protein) and gp130 [the signal transducer of interleukin-6 (IL-6)]. Thus, the...

Subject

Ciliary neurotrophic factor

Leukemia inhibitory factor receptor

Glycoprotein 130

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