Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Zeißig, Sebastian; Bürgel, Natalie; Günzel, Dorothee; Richter, J; Mankertz, Joachim; Wahnschaffe, Ulrich; J. Kroesen, A.; Zeitz, Martin; Fromm, Michael; Schulzke, JD

doi:10.1136/gut.2006.094375

Public

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Published in Gut • Jul 5, 2006

Authors:

Sebastian Zeißig

Natalie Bürgel

Dorothee Günzel

Abstract

BACKGROUND: Epithelial barrier function is impaired in Crohn's disease. AIM: To define the underlying cellular mechanisms with special attention to tight junctions. METHODS: Biopsy specimens from the sigmoid colon of patients with mild to moderately active or inactive Crohn's disease were studied in...

Subject

Tight junction

Claudin

Occludin

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