Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma

Francis, Heather; DeMorrow, Sharon; Venter, Julie; Onori, Paolo; White, Mellanie; Gaudio, Eugenio; Francis, Taylor; F. Greene, John; Tran, Steve; J. Meininger, Cynthia; Alpini, Gianfranco

doi:10.1136/gutjnl-2011-300007

Public

Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma

Published in Gut • Aug 26, 2011

Authors:

Heather Francis

Sharon DeMorrow

Julie Venter

Abstract

BACKGROUND: In several tumours the endogenous activity of histidine decarboxylase (HDC), the enzyme stimulating histamine synthesis, sustains the autocrine trophic effect of histamine on cancer progression. Cholangiocarcinoma is a biliary cancer with limited treatment options. Histamine interacts wi...

Subject

Histamine

Histidine decarboxylase

Autocrine signalling

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