Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D

Ström, Anders; Hartman, Johan; S. Foster, James; Kietz, Silke; Wimalasena, Jay; Gustafsson, Jan-Ακε

doi:10.1073/pnas.0308319100

Public

Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D

Published in Proceedings of the National Academy of Sciences • Jan 26, 2004

Authors:

Anders Ström

Johan Hartman

James S. Foster

Abstract

Estrogen receptor (ER) beta counteracts the activity of ERalpha in many systems. In agreement with this, we show in this study that induced expression of ERbeta in the breast cancer cell line T47D reduces 17beta-estradiol-stimulated proliferation when expression of ERbeta mRNA equals that of ERalpha...

Subject

Estrogen receptor

Cell growth

CDK inhibitor

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