Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

F.J. Verhaaren, Benjamin; Debette, Stéphanie; C. Bis, Joshua; A. Smith, Jennifer; Kamran Ikram, M.; H.H. Adams, Hieab; Beecham, Ashley; B. Rajan, Kumar; M. Lopez, Lorna; Barral, Sandra; A. van Buchem, Mark; van der Grond, Jeroen; V. Smith, Albert; Hegenscheid, Katrin; T. Aggarwal, Neelum; de Andrade, Mariza; J. Atkinson, Elizabeth; Beekman, Marian; Beiser, Alexa; H. Blanton, Susan; Boerwinkle, Eric; M. Brickman, Adam; Nick Bryan, R.; Chauhan, Ganesh; Chen, Christopher; Chouraki, Vincent; J. M. de Craen, Anton; Crivello, Fabrice; J. Deary, Ian; Deelen, Joris; L. De Jager, Philip; Dufouil, Carole; S.V. Elkind, Mitchell; A. Evans, Denis; Freudenberger, Paul; F. Gottesman, Rebecca; Guðnason, Vilmundur; Habes, Mohamad; R. Heckbert, Susan; Heiss, Gerardo; Hilal, Saima; Hofer, Edith; Hofman, Albert; A. Ibrahim‐Verbaas, Carla; S. Knopman, David; E. Lewis, Cora; Liao, Jiemin; C. Liewald, David; Luciano, Michelle; van der Lugt, Aad; Martinez, Oliver; Mayeux, Richard; Mazoyer, Bernard; A. Nalls, Mike; Nauck, Matthias; J. Niessen, Wiro; A. Oostra, Ben; M. Psaty, Bruce; Rice, Kenneth; I. Rotter, Jerome; von Sarnowski, Bettina; Schmidt, Helena; J. Schreiner, Pamela; Schuur, Maaike; Sidney, Stephen; Sigurðsson, Sigurður; Eline Slagboom, P.; J.M. Stott, David; C. van Swieten, John; Teumer, Alexander; Maria Töglhofer, Anna; Traylor, Matthew; Trompet, Stella; T. Turner, Stephen; Tzourio, Christophe; Uh, Hae‐Won; G. Uitterlinden, André; W. Vernooij, Meike; Jing Wang, Jing; Yin Wong, Tien; M. Wardlaw, Joanna; Gwen Windham, B.; Wittfeld, Katharina; Wolf, Christiane; B. Wright, Clinton; Yang, Qiong; Zhao, Wei; Zijdenbos, Alex; Wouter Jukema, J.; L. Sacco, Ralph; L. R. Kardia, Sharon; Amouyel, Philippe; H. Mosley, Thomas; T. Longstreth, W.; DeCarli, Charles; M. van Duijn, Cornelia; Schmidt, Reinhold; J. Launer, Lenore; J. Grabe, Hans; Seshadri, Sudha; Arfan Ikram, M.; Fornage, Myriam

doi:10.1161/circgenetics.114.000858

Public

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Published in Circulation Cardiovascular Genetics • Feb 9, 2015

Authors:

Benjamin F.J. Verhaaren

Stéphanie Debette

Joshua C. Bis

Abstract

BACKGROUND: The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducte...

Subject

Hyperintensity

Genome-wide association study

White matter

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