Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

Hirai, Hiroyuki; Tanaka, Kazuya; Yoshie, Osamu; Ogawa, Kazuyuki; KENMOTSU, K; Takamori, Yasushi; Ichimasa, Michiko; Sugamura, Kazuo; Nakamura, Masataka; Takano, Shoichi; Nagata, Kinya

doi:10.1084/jem.193.2.255

Public

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

Published in The Journal of Experimental Medicine • Jan 15, 2001

Authors:

Hiroyuki Hirai

Kazuya Tanaka

Osamu Yoshie

Abstract

Prostaglandin (PG)D2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor (DP). Involvement of DP in the formation of allergic asthma was recently demonstrated with DP-deficient mice. However, proinflammatory functions...

Subject

Prostaglandin D2

Chemotaxis

Allergic inflammation

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