A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner.

KL, Howdeshell; VS, Wilson; J, Furr; CR, Lambright; CV, Rider; CR, Blystone; AK, Hotchkiss; LE Jr, Gray

doi:10.1093/toxsci/kfn077

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A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner.

Shared by NobleBlocks on Apr 14, 2008 • 12:00 AM UTC

Authors:

Howdeshell KL

Wilson VS

Furr J

Abstract

Phthalate diesters are chemicals to which humans are ubiquitously exposed. Exposure to certain phthalates during sexual differentiation causes reproductive tract malformations in male rats. In the fetal rat, exposure to the phthalates benzylbutyl phthalate (BBP), di(n)butyl phthalate (DBP), and diet...

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