A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner

L. Howdeshell, Kembra; S. Wilson, Vickie; Furr, Johnathan; R. Lambright, Christy; V. Rider, Cynthia; R. Blystone, Chad; K. Hotchkiss, Andrew; Earl Gray, L.

doi:10.1093/toxsci/kfn077

Public

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner

Published in Toxicological Sciences • Apr 14, 2008

Authors:

Kembra L. Howdeshell

Vickie S. Wilson

Johnathan Furr

Abstract

Phthalate diesters are chemicals to which humans are ubiquitously exposed. Exposure to certain phthalates during sexual differentiation causes reproductive tract malformations in male rats. In the fetal rat, exposure to the phthalates benzylbutyl phthalate (BBP), di(n)butyl phthalate (DBP), and diet...

Subject

Phthalate

Diethyl phthalate

Testosterone (patch)

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