Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Murakami, Makoto; Naraba, Hiroaki; Tanioka, Toshihiro; Semmyo, Natsuki; Nakatani, Yoshihito; Kojima, Fumiaki; Ikeda, Tomomi; Fueki, Mai; Ueno, Akinori; Oh‐ishi, Sachiko; Kudo, Ichiro

doi:10.1074/jbc.m003505200

Public

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Published in Journal of Biological Chemistry • Oct 1, 2000

Authors:

Makoto Murakami

Hiroaki Naraba

Toshihiro Tanioka

Abstract

Here we report the molecular identification of membrane-bound glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (mPGES), a terminal enzyme of the cyclooxygenase (COX)-2-mediated PGE(2) biosynthetic pathway. The activity of mPGES was increased markedly in macrophages and osteoblasts follow...

Subject

Proinflammatory cytokine

Prostaglandin E2

Arachidonic acid

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