A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

J. Iliff, Jeffrey; Wang, Minghuan; Liao, Yonghong; A. Plogg, Benjamin; Peng, Weiguo; Andreas Gundersen, Georg; Benveniste, Helene; Edward Vates, G.; Deane, Rashid; A. Goldman, Steven; A. Nagelhus, Erlend; Nedergaard, Maiken

doi:10.1126/scitranslmed.3003748

Public

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Published in Science Translational Medicine • Aug 15, 2012

Authors:

Jeffrey J. Iliff

Minghuan Wang

Yonghong Liao

Abstract

Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain extracellular solutes, but it is not clear how solutes from the brain interstitium move from the parenchyma to the CSF. We de...

Subject

Glymphatic system

Parenchyma

Interstitial fluid

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