Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.

I, Marzo; C, Brenner; N, Zamzami; JM, Jürgensmeier; SA, Susin; HL, Vieira; MC, Prévost; Z, Xie; S, Matsuyama; JC, Reed; G, Kroemer

doi:10.1126/science.281.5385.2027

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Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.

Shared by NobleBlocks on Sep 1, 1998 • 12:00 AM UTC

Authors:

Marzo I

Brenner C

Zamzami N

Abstract

The proapoptotic Bax protein induces cell death by acting on mitochondria. Bax binds to the permeability transition pore complex (PTPC), a composite proteaceous channel that is involved in the regulation of mitochondrial membrane permeability. Immunodepletion of Bax from PTPC or purification of PTPC...

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