Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

Marzo, Isabel; Brenner, Catherine; Zamzami, Naoufal; M. Jürgensmeier, Juliane; A. Susín, Santos; L.A. Vieira, Helena; Prévost, Marie‐Christine; Xie, Zhihua; Matsuyama, Shigemi; C. Reed, John; Kroemer, Guido

doi:10.1126/science.281.5385.2027

Public

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

Published in Science • Sep 25, 1998

Authors:

Isabel Marzo

Catherine Brenner

Naoufal Zamzami

Abstract

The proapoptotic Bax protein induces cell death by acting on mitochondria. Bax binds to the permeability transition pore complex (PTPC), a composite proteaceous channel that is involved in the regulation of mitochondrial membrane permeability. Immunodepletion of Bax from PTPC or purification of PTPC...

Subject

Adenine nucleotide translocator

Voltage-dependent anion channel

Mitochondrial permeability transition pore

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