Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

C. Newby, Andrew

doi:10.1161/atvbaha.108.173898

Public

Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

Published in Arteriosclerosis Thrombosis and Vascular Biology • Sep 4, 2008

Authors:

Andrew C. Newby

Abstract

Matrix metalloproteinases (MMPs) can degrade strength-giving collagens and other structural proteins of the arterial extracellular matrix. Overproduction of MMPs by monocyte/macrophages could therefore promote atherosclerotic plaque rupture and myocardial infarction. Freshly-recruited monocyte macro...

Subject

Matrix metalloproteinase

Extracellular matrix

Macrophage

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