Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation <i>in vitro</i> and <i>in vivo</i>

Liu, Ta-Jen; LaFortune, Tiffany; Honda, Toshiyuki; Ohmori, Osamu; Hatakeyama, Shinji; Meyer, Thomas; Jackson, Dowdy; de Groot, John; Alfred Yung, W.K.

doi:10.1158/1535-7163.mct-06-0476

Public

Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

Shared by NobleBlocks on Apr 1, 2007 • 12:00 AM UTC

Authors:

Ta-Jen Liu

Tiffany LaFortune

Toshiyuki Honda

Abstract

Abstract Multiple genetic aberrations in human gliomas contribute to their highly infiltrative and rapid growth characteristics. Focal adhesion kinase (FAK) regulates tumor migration and invasion. Insulin-like growth factor-I receptor (IGF-IR), whose expression correlates with tumor grade, is involv...

Discussions