Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment

Rodin, Sergey; Antonsson, Liselotte; Niaudet, Colin; E. Simonson, Oscar; Salmela, Elina; M. Hansson, Emil; Domogatskaya, Anna; Xiao, Zhijie; Damdimopoulou, Pauliina; Sheikhi, Mona; Inzunza, José; Nilsson, Ann-Sofie; Baker, Duncan; Kuiper, Raoul; Sun, Yi; Blennow, Elisabeth; Nordenskjöld, Magnus; Grinnemo, Karl‐Henrik; Kere, Juha; Betsholtz, Christer; Hovatta, Outi; Tryggvason, Karl

doi:10.1038/ncomms4195

Public

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment

Published in Nature Communications • Jan 27, 2014

Authors:

Sergey Rodin

Liselotte Antonsson

Colin Niaudet

Abstract

Lack of robust methods for establishment and expansion of pluripotent human embryonic stem (hES) cells still hampers development of cell therapy. Laminins (LN) are a family of highly cell-type specific basement membrane proteins important for cell adhesion, differentiation, migration and phenotype s...

Subject

Cell biology

Embryonic stem cell

Inner cell mass

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