Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis

Riteau, Nicolas; Gasse, Paméla; Fauconnier, Louis; Gombault, Aurélie; Couegnat, Marion; Fick, Lizette; Kanellopoulos, Jean; Quesniaux, Valérie; Marchand‐Adam, S.; Crestani, Bruno; Ryffel, Bernhard; Couillin, Isabelle

doi:10.1164/rccm.201003-0359oc

Public

Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis

Published in American Journal of Respiratory and Critical Care Medicine • Jun 3, 2010

Authors:

Nicolas Riteau

Paméla Gasse

Louis Fauconnier

Abstract

RATIONALE: Pulmonary fibrosis is a devastating as yet untreatable disease. We previously investigated the endogenous mediators released on lung injury and showed that uric acid is a danger signal activating Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in lung inflammation...

Subject

Medicine

Inflammation

Pannexin

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