Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis

Jiménez Calvente, Carolina; Sehgal, Alfica; Popov, Yury; Oock Kim, Yong; F. Zevallos, Victor; Şahin, Uğur; Diken, Mustafa; Schuppan, Detlef

doi:10.1002/hep.27936

Public

Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis

Published in Hepatology • Jun 19, 2015

Authors:

Carolina Jiménez Calvente

Alfica Sehgal

Yury Popov

Abstract

UNLABELLED: Fibrosis accompanies the wound-healing response to chronic liver injury and is characterized by excessive hepatic collagen accumulation dominated by collagen type I. Fibrosis often progresses to cirrhosis. Here we present in vivo evidence of an up to 90% suppression of procollagen α1(I) ...

Subject

Procollagen peptidase

Small interfering RNA

Fibrosis

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