Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells

de Souza Rocha Simonini, Pedro; Breiling, Achim; Vishal Gupta, N.; Malekpour, Mahdi; Youns, Mаhmoud; Omranipour, Ramesh; Malekpour, Fatemeh; Volinia, Stefano; M. Croce, Carlo; Najmabadi, Hossein; Diederichs, Sven; Şahin, Özgür; Mayer, Doris; Lyko, Frank; D. Hoheisel, Jörg; Riazalhosseini, Yasser

doi:10.1158/0008-5472.can-10-1318

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Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells

Published in Cancer Research • Oct 26, 2010

Authors:

Pedro de Souza Rocha Simonini

Achim Breiling

N. Vishal Gupta

Abstract

Estrogen receptor α (ERα) upregulation causes abnormal cell proliferation in about two thirds of breast cancers, yet understanding of the underlying mechanisms remains incomplete. Here, we show that high expression of the microRNA miR-375 in ERα-positive breast cell lines is a key driver of their pr...

Subject

microRNA

Estrogen receptor

Cancer research

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