Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.

N, Itano; T, Sawai; M, Yoshida; P, Lenas; Y, Yamada; M, Imagawa; T, Shinomura; M, Hamaguchi; Y, Yoshida; Y, Ohnuki; S, Miyauchi; AP, Spicer; JA, McDonald; K, Kimata

doi:10.1074/jbc.274.35.25085

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Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.

Shared by NobleBlocks on Aug 1, 1999 • 12:00 AM UTC

Authors:

Itano N

Sawai T

Yoshida M

Abstract

Three mammalian hyaluronan synthase genes, HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and compared the enzymatic properties of these three HAS proteins. Expression of any of these genes in COS-1 cells or rat 3Y1 fibroblasts yielded de novo formation of a hyaluro...

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