Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties

Itano, Naoki; Sawai, Takahiro; Yoshida, Mamoru; Lenas, Petros; Yamada, Yoichi; Imagawa, Michiko; Shinomura, Tamayuki; Hamaguchi, Michinari; Yoshida, Yuko; Ohnuki, Youji; Miyauchi, Satoshi; P. Spicer, Andrew; A. McDonald, John; Kimata, Koji

doi:10.1074/jbc.274.35.25085

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Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties

Published in Journal of Biological Chemistry • Aug 1, 1999

Authors:

Naoki Itano

Takahiro Sawai

Mamoru Yoshida

Abstract

Three mammalian hyaluronan synthase genes, HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and compared the enzymatic properties of these three HAS proteins. Expression of any of these genes in COS-1 cells or rat 3Y1 fibroblasts yielded de novo formation of a hyaluro...

Subject

Gene isoform

Enzyme

Biochemistry

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