Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

E. Klunk, William; Engler, Henry; Nordberg, Agneta; Wang, Yanming; Blomqvist, G.; P. Holt, Daniel; Bergström, Mats; Savitcheva, Irina; Huang, Guofeng; Estrada, Sergio; Ausén, Birgitta; L. Debnath, Manik; Barletta, Julien; C. Price, Julie; Sandell, Johan; J. Lopresti, Brian; Wall, Anders; Koivisto, P.; Antoni, Gunnar; A. Mathis, Chester; Långström, Bengt

doi:10.1002/ana.20009

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

Published in Annals of Neurology • Jan 21, 2004

Authors:

William E. Klunk

Henry Engler

Agneta Nordberg

Abstract

This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of associa...

Subject

Pittsburgh compound B

Alzheimer's disease

Amyloid (mycology)

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