The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow

Peled, Amnon; Grabovsky, Valentin; Habler, Liliana; Sandbank, Judith; Arenzana-Seisdedos, Frenando; Petit, Isabelle; Ben‐Hur, Herzl; Lapidot, Tsvee; Alon, R.

doi:10.1172/jci7615

Public

The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow

Published in Journal of Clinical Investigation • Nov 1, 1999

Authors:

Amnon Peled

Valentin Grabovsky

Liliana Habler

Abstract

The chemokine SDF-1 plays a central role in the repopulation of the bone marrow (BM) by circulating CD34(+) progenitors, but the mechanisms of its action remain obscure. To extravasate to target tissue, a blood-borne cell must arrest firmly on vascular endothelium. Murine hematopoietic progenitors w...

Subject

Cell biology

Integrin

Selectin

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