Truncations of Titin Causing Dilated Cardiomyopathy

S. Herman, Daniel; Lam, Lien; R.G. Taylor, Matthew; Wang, Libin; Teekakirikul, Polakit; C. Christodoulou, Danos; Conner, Lauren; R. DePalma, Steven; McDonough, Barbara; Sparks, Elizabeth; Lin Teodorescu, Debbie; L. Cirino, Allison; R. Banner, Nicholas; J. Pennell, Dudley; Graw, Sharon; Merlo, Marco; Di Lenarda, Andrea; Sinagra, Gianfranco; Martijn Bos, J.; J. Ackerman, Michael; N. Mitchell, Richard; E. Murry, Charles; K. Lakdawala, Neal; Y. Ho, Carolyn; J.R. Barton, Paul; A. Cook, Stuart; Mestroni, Luisa; G. Seidman, Jonathan; E. Seidman, Christine

doi:10.1056/nejmoa1110186

Public

Truncations of Titin Causing Dilated Cardiomyopathy

Published in New England Journal of Medicine • Feb 15, 2012

Authors:

Daniel S. Herman

Lien Lam

Matthew R.G. Taylor

Abstract

BACKGROUND: Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently analyzed for cardiomyopathy mutations because of its enormous size. METHODS: We analyzed TTN in 312 subjects with dilated...

Subject

Titin

Medicine

Dilated cardiomyopathy

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