Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism

Zani, Augusto; Cananzi, Mara; Fascetti Leon, Francesco; Lauriti, Giuseppe; V. Smith, Virpi; Bollini, Sveva; Ghionzoli, Marco; D’Arrigo, Antonello; Pozzobon, Michela; Piccoli, Martina; N. Hicks, Amy; A. Wells, Jack; Siow, Bernard; J. Sebire, Neil; E. Bishop, Colin; Leon, Alberta; Atala, Anthony; F. Lythgoe, Mark; Pierro, Agostino; Eaton, Simon; De Coppi, Paolo

doi:10.1136/gutjnl-2012-303735

Public

Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism

Published in Gut • Mar 24, 2013

Authors:

Augusto Zani

Mara Cananzi

Francesco Fascetti Leon

Abstract

OBJECTIVE: Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity and mortality in neonates and alternative strategies are needed. Stem cells have become a therapeutic option for other intestinal diseases, which share some features with NEC. We tested the hypothesis that amni...

Subject

Stem cell

Barrier function

Cancer research

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