Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

P. C. Cole, S.; Bhardwaj, G.; H. Gerlach, J.; E. Mackie, J.; E. Grant, C.; C. Almquist, K.; J. Stewart, A.; U. Kurz, E.; M. V. Duncan, A.; G. Deeley, R.

doi:10.1126/science.1360704

Public

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

Shared by NobleBlocks on Dec 4, 1992 • 12:00 AM UTC

Authors:

S. P. C. Cole

G. Bhardwaj

J. H. Gerlach

Abstract

The doxorubicin-selected lung cancer cell line H69AR is resistant to many chemotherapeutic agents. However, like most tumor samples from individuals with this disease, it does not overexpress P-glycoprotein, a transmembrane transport protein that is dependent on adenosine triphosphate (ATP) and is a...

Discussions