<i>EML4-ALK</i> Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer

Koivunen, Jussi; H. Mermel, Craig; Zejnullahu, Kreshnik; Murphy, Carly; Lifshits, Eugene; J. Holmes, Alison; Geun Choi, Hwan; Kim, Jhingook; Y. Chiang, Derek; K. Thomas, Roman; Lee, Jinseon; G. Richards, William; J. Sugarbaker, David; T. Ducko, Christopher; I. Lindeman, Neal; Marcoux, Judith; A. Engelman, Jeffrey; S. Gray, Nathanael; Lee, Charles; Meyerson, Matthew; A. Jänne, Pasi

doi:10.1158/1078-0432.ccr-08-0168

Public

EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer

Published in Clinical Cancer Research • Jul 1, 2008

Authors:

Jussi Koivunen

Craig H. Mermel

Kreshnik Zejnullahu

Abstract

PURPOSE: The EML4-ALK fusion gene has been detected in approximately 7% of Japanese non-small cell lung cancers (NSCLC). We determined the frequency of EML4-ALK in Caucasian NSCLC and in NSCLC cell lines. We also determined whether TAE684, a specific ALK kinase inhibitor, would inhibit the growth of...

Subject

Cancer research

Epidermal growth factor receptor

Protein kinase B

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