Immunochemical Evidence for Protein Abnormalities in Platelets from Patients with Glanzmann's Thrombasthenia and Bernard-Soulier Syndrome

Hagen, Inger; T. Nurden, Alan; J. Bjerrum, Ole; Olav Solum, Nils; Caen, Jacques

doi:10.1172/jci109719

Public

Immunochemical Evidence for Protein Abnormalities in Platelets from Patients with Glanzmann's Thrombasthenia and Bernard-Soulier Syndrome

Published in Journal of Clinical Investigation • Mar 1, 1980

Authors:

Inger Hagen

Alan T. Nurden

Ole J. Bjerrum

Abstract

Crossed immunoelectrophoresis of Triton X-100 solubilized proteins from normal and abnormal platelets was performed with rabbit antibodies raised against normal platelets. In Bernard-Soulier platelets protein 13 was not detected, and neither the amphiphilic (probably GP Ib) nor the hydrophilic (glyc...

Subject

Thrombasthenia

Glanzmann's thrombasthenia

Platelet

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