MicroRNA‐199a targets <i>CD44</i> to suppress the tumorigenicity and multidrug resistance of ovarian cancer‐initiating cells

Cheng, Weiwei; Liu, Te; Wan, Xiaoping; Gao, Yongtao; Wang, Hui

doi:10.1111/j.1742-4658.2012.08589.x

Public

MicroRNA‐199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer‐initiating cells

Shared by NobleBlocks on Apr 24, 2012 • 12:00 AM UTC

Authors:

Weiwei Cheng

Te Liu

Xiaoping Wan

Abstract

In ovarian cancer, CD44 + /CD117 + stem cells, also known as cancer‐initiating cells (CICs), are highly proliferative, have a low degree of differentiation, and are resistant to chemotherapeutics. Therefore, the CD44 + /CD117 + subpopulation is thought to be an important target for novel therapeutic...

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