MicroRNA‐199a targets <i>CD44</i> to suppress the tumorigenicity and multidrug resistance of ovarian cancer‐initiating cells

Cheng, Weiwei; Liu, Te; Wan, Xiaoping; Gao, Yongtao; Wang, Hui

doi:10.1111/j.1742-4658.2012.08589.x

Public

MicroRNA‐199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer‐initiating cells

Published in FEBS Journal • Apr 12, 2012

Authors:

Weiwei Cheng

Te Liu

Xiaoping Wan

Abstract

In ovarian cancer, CD44(+) /CD117(+) stem cells, also known as cancer-initiating cells (CICs), are highly proliferative, have a low degree of differentiation, and are resistant to chemotherapeutics. Therefore, the CD44(+) /CD117(+) subpopulation is thought to be an important target for novel therape...

Subject

Ovarian cancer

Transfection

CD44

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