In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo

Villenave, Rémi; Thavagnanam, Surendran; Sarlang, Séverine; C. Parker, Jeremy; Douglas, Isobel; Skibiński, Grzegorz; G. Heaney, Liam; P. McKaigue, James; Coyle, Peter; D. Shields, Michael; F. Power, Ultan

doi:10.1073/pnas.1110203109

Public

In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo

Published in Proceedings of the National Academy of Sciences • Mar 12, 2012

Authors:

Rémi Villenave

Surendran Thavagnanam

Séverine Sarlang

Abstract

Respiratory syncytial virus (RSV) is the major viral cause of severe pulmonary disease in young infants worldwide. However, the mechanisms by which RSV causes disease in humans remain poorly understood. To help bridge this gap, we developed an ex vivo/in vitro model of RSV infection based on well-di...

Subject

Biology

Immunology

Respiratory epithelium

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