Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen, Joris; Beekman, Marian; Uh, Hae‐Won; Broer, Linda; L. Ayers, Kristin; Tan, Qihua; Kamatani, Yoichiro; M. Bennet, Anna; Tamm, Riin; Trompet, Stella; F. Guðbjartsson, Daníel; Flachsbart, Friederike; Rose, Giuseppina; Viktorin, Alexander; Fischer, Krista; Nygaard, Marianne; J. Cordell, Heather; Crocco, Paolina; B. van den Akker, Erik; Böhringer, Stefan; Helmer, Quinta; P. Nelson, Christopher; Saunders, Gary; Alver, Maris; Andersen‐Ranberg, Karen; E. Breen, Marie; van der Breggen, Ruud; Caliebe, Amke; Capri, Miriam; Cevenini, Elisa; Collerton, Joanna; Dato, Serena; Davies, Karen; Ford, Ian; Gampe, Jutta; Garagnani, Paolo; J. C. de Geus, Eco; Harrow, Jennifer; van Heemst, Diana; T. Heijmans, Bastiaan; Heinsen, Femke‐Anouska; Hottenga, Jouke‐Jan; Hofman, Albert; Jeune, Bernard; V. Jónsson, Pálmi; Lathrop, Mark; Lechner, Doris; Martín-Ruiz, Carmen; McNerlan, Susan; Mihailov, Evelin; Montesanto, Alberto; P. Mooijaart, Simon; M. Murphy, Anne; A. Nøhr, Ellen; Paternoster, Lavinia; Postmus, Iris; Rivadeneira, Fernando; A. Ross, Owen; Salvioli, Stefano; Sattar, Naveed; Schreiber, Stefan; Stefánsson, Hreinn; J. Stott, David; Tiemeier, Henning; G. Uitterlinden, André; G. J. Westendorp, Rudi; Willemsen, Gonneke; J. Samani, Nilesh; Galán, Pilar; I. A. Sørensen, Thorkild; I. Boomsma, Dorret; Wouter Jukema, J.; Maeve Rea, Irene; Passarino, Giuseppe; J. M. de Craen, Anton; Christensen, Kaare; Nebel, Almut; Stefánsson, Kári; Metspalu, Andres; K. E. Magnusson, Patrik; Blanché, Hélène; Christiansen, Lene; B. L. Kirkwood, Thomas; M. van Duijn, Cornelia; Franceschi, Claudio; J. Houwing‐Duistermaat, Jeanine; Eline Slagboom, P.

doi:10.1093/hmg/ddu139

Public

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Published in Human Molecular Genetics • Mar 31, 2014

Authors:

Joris Deelen

Marian Beekman

Hae‐Won Uh

Abstract

The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent...

Subject

Biology

Longevity

Locus (genetics)

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